Investigating the Role of JAK/STAT Pathway on Dasatinib-Induced Apoptosis for CML Cell Model K562.

نویسندگان

  • Ceyda Tunakan Dalgıç
  • Burçin Tezcanlı Kaymaz
  • Melda Cömert Özkan
  • Ayşegül Dalmızrak
  • Fahri Şahin
  • Güray Saydam
چکیده

We aimed to evaluate the cytotoxic and apoptotic effects of dasatinib (BMS-354825) on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on dasatinib-induced apoptosis. The results showed that dasatinib decreased proliferation and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT5A and STAT5B genes were significantly reduced in dasatinib-treated K562 cells. These data indicated that STAT inhibition by dasatinib might be therapeutic in JAK/STAT pathway-associated malignancies after confirmation with clinical studies.

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عنوان ژورنال:
  • Clinical lymphoma, myeloma & leukemia

دوره 15 Suppl  شماره 

صفحات  -

تاریخ انتشار 2015